notSinceTheIncident
64154
1196
12
https://www.euronews.com/next/2023/12/20/scientists-discover-the-first-new-antibiotics-in-over-60-years-using-ai
I post stuff from goodnews.eu
It makes me feel better so I like to share it
https://www.euronews.com/next/2023/05/09/sweden-is-building-the-worlds-first-permanent-electrified-road-for-evs-to-charge-while-dri
https://english.elpais.com/health/2023-12-11/three-minutes-of-intense-exercise-a-day-can-improve-cardiovascular-health-in-sedentary-women.html
Merry Christmas, you silly bastards.
AxelBeingCivil
New antibiotics are discovered reasonably frequently. It's not finding new antibiotics that's the trick; it's finding broad-spectrum antibiotics that don't make humans sick that's the problem. Gotta remember: We have, in our cells, little captive bacteria called mitochondria. Antibiotics that target bacterial cell wall processes are fine but ones that target bacterial ribosomes mess us up good.
bl0ke
I do short bursts of exercise every day. Sometimes, twice a day.
BubblesTheFish
roads no matter how electrified suck dick. more trains
UpUpDownQuarks
Maybe we should stop giving antibiotics to kettle just a thought…
Lorks
Thank you for posting :)
notSinceTheIncident
Anytime!
Bigbadtacomuncher
#2 we are? Nobody told anyone here. I did some googling and found 2 different roads in sweden. One built 2017, one in 2018, both calling themselves the first one.
Sorrontis
how long until it's over prescribed again and bacteria become immune again?
TheMightyMoto
Neat
PlankTableGo
#2 You've got boost power!
idiotsonfire
One of my favorite games of all time. Fuck Nintendo for throwing that franchise into the dumpster.
YouMayFindThisMildlyInteresting
That looks way better in a thumbnail than I remember on the Gamecube.
PlankTableGo
Chances are, the original footage is from the Dolphin Emulator.
colmustard1985
Time to bust out the drr matts again
gablestout
Is it about the Dacia Sandero?!
idiotsonfire
No!
dh4mpyr
Hay ai. This is life, kill it
TheBluntSoldier
That road is gonna smell like BBQ lol
MrHappySmiles
#1 was this made by AI? J/k.. what’s being shows is the disk diffusion method of drug effectiveness. The clear plaque in the bed of microbial growth shows the effectiveness of the drug. When many are tested, the molecular size of the drug can affect diffusion through the medium, and another chart is referenced to read the final effectiveness of the plaque made by the given drug.
ShatteredThought
Knowing how bad MRSA is getting (there are some strains that are resistant to all currently in use antibiotics), that is great news to hear. I also hope that we start making big strides in phage therapy, to help get around antibiotic resistance.
TheBishopofBanterbury
I hope we can develop better antivirals, too. If you've got a virus, what are our options?
satsukeshi
Prob the type of bacteria that eats viruses
newsguycraigevans
wabitgirl
It would help if people would actually follow doctor recommendations for completing antibiotic schedules as well, but new drugs are hype af.
ShatteredThought
Oh absolutely. That and overprescription is why we are where we are. :c But yay, new drugs!
wabitgirl
I have a distinct childhood memory of my mother, who was a physician at the time, yelling at a doctor who was filling in for my PCP because I had a fever and the person, without doing any kind of culture or proper check said, "Yeah, I'm gonna proscribe your antibiotics." Turns out it was a viral infection, and the antibiotics would have done NOTHING. Overprescription is such a huge problem.
notblubber
Drug deployment is the issue with our old antibiotics. The reason we have drug resistant bacteria isn't so much overuse in humans, it's because it's being shovelled into food animals to increase profits. If we develop a new class of drugs, we can't saturate the environment with them.
newsguycraigevans
And_it's_gone.jpeg
charlotte240
he said, "FOOD ANIMALS"
BatmanAndCradleRobin
I mean humans using them on themselves for both valid reasons an non valid reasons like antibacterial soap are a huge problem too
Thesomanyethcrazycatlady
As someone who taught microbio practicals, including the yearly experiments with students putting their dirty/washed hands (and lots more) on petridishes, I would like to emphasize that normal soap is perfectly "antibacterial" already (after drying your hands) and that you need >4 layers/sheets of toilet paper for wiping your ass.
Wyrdbunny
We did the hand sanitation experiment in my microbio class too (when I was a student), but I guess I skipped out on the ass wiping day. Can't say I am sad. One girl brought in a swab from the seafood counter at the grocery she worked at AFTER it had been cleaned. She cultured something that our professor deemed deadly enough to destroy immediately. I wish I remember what it was.
FantomNemisis
For single ply or double ply?
Wyrdbunny
Asking the important questions!
davethesailor
This will lead to a new form of abuse where people install functions on their vehicles to 'harvest" the available power. I could load up my automated weaving machine and just drive around on free power using free power to profit. LOL
OliverOtter
This is not the first new antibiotic in decades, there have been several other new classes recently. The problem has been that early results in vitro have not translated to usable drugs. Pexiganan for example was 100X less toxic to mammalian cells than anything else in its class, while being just as effective against antibiotic-resistant germs. It really seemed to be THE ONE. It still killed living human tissue and made things WORSE when tested in living people.
twelvoclocklevel
#3 That *is* good news! + I still haven't gone blind
mikeatike
#2 solar fricken roadways
Scrambles667
Looks like we're going to have to subscribe to a monthly plan to drive on the road. Hooray for capitalism
HapilyDamaged
maybe I won't be allergic to this one
tyrunn
I bet I'm allergic to that one too
Hakunayatata
The new antibiotics? That was my thought as well lol
TheFastpaws
#1 It will get ruined by all the idiots who "feel better" and stop taking the meds. So once again the wrong kind survives.
nevergoingtogiveyouupnevergoingtoletyoudown
Most 1st world countries use antibiotic+phage therapy. See, the neat thing is, for bacteria, to resist one they have to give up resistance to the other. If you attack them with both, one of the two will kill it.
guardian19d
This is how the zombie apocalypse starts.
cellfreeDNA
We’re still fucked if it’s a fungus, which it will be.
guardian19d
Hold up... is it the fun fungus or unfun fungus?
cellfreeDNA
Decidedly un-fun.
thehoesenone
I always knew "short and intense" was a good thing...
notSinceTheIncident
I also liked this study. I hate running on a treadmill for 30 minutes at the gym. I'd rather sprint for 60 seconds. This confirms my bias :)
AltruisticDefenestrator
New antibiotic is good, will buy us a couple more years!
JabesMcJabesface
Possibly a couple more decades, truly.
toolazytoname
Unfortunately, we would have lots of new antibiotics if there was money in it. Pharma doesn't like to spend on it because there is a rosk of diminished returns if resistance occurs before they they make their money. AI will seriously reduce the work needed to produce new ones, but still no guarantee they will make them.
totallynotagoat
Nah, American farm industry will be pumping it into cattle and poultry tomorrow.
jesuisgur
A couple more years is the word. There's now antibioresistance to everything we've produced. Just think that before antibiotics 1 skin infection out of 9 led to death. People who feed low-grade antibiotics to cattle to fatten them faster, and thus caused resistances to start, should be shot.
Okebel
If it's not overused
Kuiper
Honestly though, the fact that they found it through machine learning is the cool part. Since it can be refined to include all kinds of other things. In the end machine learning might unlock a whole host of drugs, and treatment options.
FrogDelay
Yeah think about target therapy for cancer where machine learning can find the exact dna damage and combine with CRISPR to fix it
TeaOverdose
robots should stop trying to become artists and become doctors, make their parents proud.
Lonecoon
New class of antibiotic is great. I hope this came from the newfound ability to grow soil bacteria.
PeeterGrant
If it cures an infection that would end up killing you, then it buys you a lot more than that.
AltruisticDefenestrator
I think mostly everyone understood that we were talking about civilization as a whole... When everyone starts dying from pneumonia again we're in a bad spot.
AxelBeingCivil
There *are* vaccines against pneumonia nowadays. Most people who aren't immunocompromised aren't at severe risk. Which isn't to say it isn't a problem, because the lives of the immunocompromised matter too, but it's not "everyone starts dying" territory.
AltruisticDefenestrator
Yeah pneumonia is just one example, perhaps not the best. There is a -heap- of other pathogens to justly worry about, MRSA being one. Point is that this is a looming full on shitstorm event that we're not doing enough to fix.
AxelBeingCivil
MRSA is a problem but it's more or less already here. At present, adaptations of MRSA tend to get outcompeted by non-resistant populations of the bacterium, since the adaptations aren't advantageous outside a hospital setting. It's not likely to reach 100% prevalence in the bacterial population. It's already causing increased deaths in hospitals but... It's pretty much at the level it's going to get to.
TheBishopofBanterbury
Did you read the article? This vaccine is for MRSA. They did what you wanted. We're there.
JimmyWalkerTexasRanger
Yes. A couple more years.
AltruisticDefenestrator
Oh yeah, we're fucked long term...
ChosenChaos
In the long enough term, EVERYTHING is fucked
AxelBeingCivil
Not really. There's methods for developing new antibiotics. We just need to look at it more like an ongoing battle, rather than something we'll ever just "win".
AltruisticDefenestrator
Kinda yes really, as things stand currently. First new antibiotic in six decades. Things might advance, i certainly hope so. If they don't we will be back to thoughts and prayers.
AxelBeingCivil
What're you talking about? Even if we go as broad as possible here, diarylquinolines were identified in 2010. OM-targeting antibiotics were only first identified in 2015.